Log in or Register for enhanced features | Forgotten Password?
White Papers | Suppliers | Events | Report Store | Companies | Dining Club | Medical Devices | Videos
Contract Research & Services
Clinical Trials
Return to: PBR Home | Contract Research & Services | Clinical Trials | White Papers
Search Refinements

Clinical Trials White Papers

View white papers from other Pharmaceutical sectors:
46-60 of 140 results
Renal Impairment Studies in Early Development Services: Innovative Patient Pharmacology Models for Phase I-IIa Support
| By PRA Health Sciences
It is recommended to have renal impairment trials conducted relatively early in the clinical development process, because the outcome may influence the patient population as well as the inclusion and exclusion criteria of Phase II and III trials. The timing of these trials is generally before or in parallel with Phase II.
Contract Research & Services > Clinical Trials > White Papers
Seamless Drug Development
| By PRA Health Sciences
The success rate of drug development has been studied extensively over the years and discussed in numerous publications. In an important recent paper by Hay et al (Nat Biotechnol. 2014;32:40-51), the overall likelihood of FDA approval for products entering clinical phase was estimated at approximately 10%.
Contract Research & Services > Clinical Trials > White Papers
Point of Care Testing in Clinical Trials
| By Woodley Equipment Company
Point of care (POC) testing is diagnostic testing performed in the vicinity of the patient, avoiding the need to send samples to a central laboratory. Results generated by POC devices can be utilised in clinical trials as decision-makers prior to administering treatments or results can be used as actual trial data.
Contract Research & Services > Clinical Trials > White Papers
User vs. Software-Dependent Variability of ELISPOT Counts Obtained from ten Different Laboratories
| By CTL Laboratories
In ELISPOT assays, cytokine spots produced by antigen-specific T cells show a broad spectrum of sizes and densities over variable background. Therefore, even experienced investigators are likely to come up with different spot counts when subjectively judging the minimal spot size/density to be counted and the maximal spot size for the cut off between singlecell-derived spots vs. those created by cell clusters. This study aims to find out whether statistics-based automated gating can harmonize spot counts obtained in different laboratories.
Contract Research & Services > Clinical Trials > White Papers
ELISPOT Assays Provide Reproducible Results Among Different Laboratories for T-cell Immune Monitoring - Even in Hands of ELISPOT's Inexperienced Investigators
| By CTL Laboratories
Measurements of antibodies in bodily fluids (e.g., by ELISA) have provided robust and reproducible results for decades and such assays have been validated for monitoring of B-cell immunity. In contrast, measuring T-cell immunity has proven to be a challenge due to the need to test live cells in functional assays ex vivo. Several previous efforts looking into the reproducibility of ex vivo T-cell assays between different laboratories, or even within the same laboratory, have provided rather discouraging results.
Contract Research & Services > Clinical Trials > White Papers
How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?
| By CTL Laboratories
Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to HLA-Class I molecules. There is extensive knowledge on individual HLA-alleles’ peptide binding requirements and for many antigens immunogenic peptides have been defined. The 32 individual peptides that comprise the CEF peptide pool represent such well-defined peptide determinants for Cytomegalo, Epstein Barr, and Flu virus. We tested 42 healthy human donors on the accuracy of these peptide predictions.
Contract Research & Services > Clinical Trials > White Papers
Publications by Theme
| By CTL Laboratories
For over 15 years, Prof. Lehmann and the team of scientists working with him have been focused on establishing the scientific foundations of ELISPOT assays and to test the utility of the technology in various fields of T cell diagnostics. CTL’s peer-reviewed publications are listed here by theme with the hopes of providing a useful reference for your research.
Contract Research & Services > Clinical Trials > White Papers
Characterisation of the CMV-Specific CD4 Cell Response
| By CTL Laboratories
Most humans become infected with HCMV. Typically, the immune system controls the infection, but the virus persists and can reactivate in states of immunodeficiency. While the HCMV-specific CD8 cell and antibody response has been accessible to investigation, studies of the CD4 cell subsets have been limited by the low frequency of the antigen-specific CD4 cells in PBMC.
Contract Research & Services > Clinical Trials > White Papers
Contract Manufacturing
| By LABORATORIOS INIBSA
LABORATORIOS INIBSA is a pharmaceutical company with over 60 years of experience. We belong to the Group Inibsa. We provide products and services to group companies, such as Biotools, Keramat, Inibsa Portugal, Dental and Hospital, as well as other pharmaceutical companies through our contract manufacturing division.
Contract Research & Services > Clinical Trials > White Papers
Signed by Syncom - Designing Chemistry in 25 Milestones
| By Syncom BV pbr
There are so many reasons to be proud of this company. In the first 25 years of Syncoms’ existence, we have truly made a contribution to science, the pharmaceutical industry, the health of many people across all continents, to the economy of our city (Groningen), as well as to the careers and lives of employees and former employees.
Contract Research & Services > Clinical Trials > White Papers
Syncom Catalogue
| By Syncom BV pbr
Click here to download our catalogue of products.
Contract Research & Services > Clinical Trials > White Papers
Softigel Technologies Brochure
| By Softigel pbr
From selecting the best gelatin source, throughout the soft gelatin capsule development, manufacturing, labeling and packaging process, until delivering a final product to your warehouse with supporting marketing strategies, SoftiGel is vertically integrated to fulfill your needs and deliver the best drug to any marketplace in the world.
Contract Research & Services > Clinical Trials > White Papers
SoftiGel Product Catalogue
| By Softigel pbr
Download our whitepaper for details of our pharmaceutical capsules and products.
Contract Research & Services > Clinical Trials > White Papers
46-60 of 140 results