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How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?

Published 06 May 2014 | By CTL Laboratories

Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to HLA-Class I molecules. There is extensive knowledge on individual HLA-alleles’ peptide binding requirements and for many antigens immunogenic peptides have been defined. The 32 individual peptides that comprise the CEF peptide pool represent such well-defined peptide determinants for Cytomegalo, Epstein Barr, and Flu virus. We tested 42 healthy human donors on the accuracy of these peptide predictions.

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How Frequently are Predicted Peptides Actually Recognised by CD8 Cells?