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ThromboGenics Microplasmin meets TG-MV-007 trial primary endpoint

PBR Staff Writer Published 01 September 2010

ThromboGenics' second Phase III trial (TG-MV-007) assessing Microplasmin for the non-surgical treatment of vitreomacular adhesion (VMA) has met the primary endpoint.

ThromboGenics said that 25.3% of the 245 Microplasmin treated patients achieved resolution of their VMA at 28 days, compared to 6.2% of the 81 patients who received a placebo injection.

Microplasmin was shown to be even more effective in patients without epiretinal membrane when compared to placebo treated patients.

Reportedly, the TG-MV-007 trial also showed that Microplasmin was highly effective in treating patients who had been diagnosed with full thickness macular hole (FTMH).

The TG-MV-007 study also evaluated the visual acuity (VA) of patients which demonstrated that at the end of the study 22% of the Microplasmin treated patients had achieved at least a 10 letter (2 lines) improvement in VA without the need for vitrectomy.

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