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Realm Therapeutics doses first patient in phase 2 study of PR022 to treat atopic dermatitis
Realm Therapeutics announced that the first patient has been dosed in its Phase 2 study of PR022, the Company's proprietary topical gel formulation of high concentration hypochlorous acid, for the treatment of atopic dermatitis.
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AbbVie’s risankizumab meets all primary endpoints in fourth phase 3 psoriasis trial
By PBR Staff Writer
AbbVie’s psoriasis drug risankizumab (150 mg) has met all the primary endpoints in the two phases of a fourth pivotal phase 3 clinical trial in patients with moderate to severe plaque psoriasis.
Contract Research & Services > Clinical Trials > News
NIH and partners commence HIV vaccine efficacy trial
The National Institutes of Health (NIH) and partners have started a clinical trial to evaluate whether an experimental HIV vaccine regimen is safe and effective in prevention of HIV infection.
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Revance Therapeutics plans phase 3 program for RT002 injectable to treat cervical dystonia
Revance Therapeutics has completed its End-of-Phase 2 meeting with the US Food and Drug Administration (FDA) and has received scientific advice from the Europe Medicines Agency (EMA) regarding DaxibotulinumtoxinA for Injection (RT002) for the treatment of cervical dystonia.
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Novartis and Amgen’s erenumab succeeds in phase 3 episodic migraine trial
By PBR Staff Writer
Novartis and Amgen’s human monoclonal antibody erenumab has succeeded in a phase 3 study by demonstrating significant and sustained efficacy in the prevention of episodic migraine.
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Viking’s VK5211 meets primary endpoint in phase 2 hip fracture trial
By PBR Staff Writer
Viking Therapeutics’ hip fracture treatment VK5211 has met primary endpoint in a 12-week phase 2 clinical trial.
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Takeda starts phase 1 trial of Zika virus vaccine candidate
By PBR Staff Writer
Japan's Takeda Pharmaceutical has started a phase 1 clinical trial of its purified, inactivated, alum-adjuvanted, whole Zika virus vaccine candidate, TAK-426.
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Biothera signs cancer immunotherapy clinical trial collaboration deal with Genentech
Biothera Pharmaceuticals has entered into a clinical trial collaboration agreement with Genentech to assess the safety and efficacy of Biothera’s Imprime PGG in combination with Genentech’s atezolizumab (TECENTRIQ), an anti-PD-L1 antibody, and bevacizumab (AVASTIN), an anti-VEGF antibody, to treat patients with metastatic colorectal cancer.
Contract Research & Services > Clinical Trials > News
Regeneron’s eye-drug combination fails in two Phase 2 studies
By PBR Staff Writer
Regeneron Pharmaceuticals announced that results from two Phase 2 studies that added the angiopoietin2 (Ang2) antibody nesvacumab to EYLEA (aflibercept) Injection did not provide enough differentiation to warrant phase 3 development.
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ViiV Healthcare begins third phase III HIV trial of cabotegravir/rilpivirine regimen
ViiV Healthcare, a joint venture of GSK, Pfizer and Shionogi, has commenced a phase III study with a two-drug regimen of its long-acting, injectable cabotegravir and Janssen Sciences Ireland’s long-acting injectable rilpivirine in virally suppressed adults with HIV-1 infection.
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Cancer Research UK to use Astra Zeneca’s AZD1775 in head and neck cancer trial
By PBR Staff Writer
UK researchers are all set to launch an early-stage trial to evaluate an experimental drug from Astra Zeneca’s for improving the treatment of head and neck cancer.
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Cytokinetics’ ALS treatment tirasemtiv fails to meet primary endpoint in phase 3 study
Cytokinetics has announced that international phase 3 clinical trial of tirasemtiv in patients with amyotrophic lateral sclerosis (ALS) has did not meet the primary endpoint.
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Research finds gastric acid suppressant lansoprazole could target tuberculosis
By PBR Staff Writer
A new research in the UK suggests that a cheap and commonly used drug to treat heartburn, gastritis and ulcers has the potential to target Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB).
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European Prevention of Alzheimer’s Dementia Consortium opens six new study sites
The European Prevention of Alzheimer’s Dementia Consortium (EPAD) is enrolling research participants at six new sites, which takes the total to ten centers across six European countries.
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Summit completes initial dosing trials on Duchenne muscular dystrophy drug
By PBR Staff Writer
Summit Therapeutics has completed the half-way stage of dosing of its Duchenne Muscular Dystrophy (DMD) candidate ezutromid in a 48-week phase 2 trial, dubbed PhaseOut DMD.
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