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GSK begins phase III trial of Benlysta, rituximab combo in systemic lupus erythematosus
GSK has commenced a phase III trial to evaluate Benlysta (belimumab) in combination with rituximab in adult patients with systemic lupus erythematosus (SLE).
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Arena’s etrasimod meets primary and secondary endpoints in ulcerative colitis trial
Arena Pharmaceuticals has reported positive topline phase 2 results from the OASIS trial for etrasimod, an investigational, once-daily, orally administered, selective sphingosine 1-phosphate (S1P) receptor modulator in development for the treatment of ulcerative colitis (UC).
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Heron’s pain drug succeeds in phase 3 bunionectomy and hernia repair trials
By PBR Staff Writer
Heron Therapeutics’ pain drug HTX-011 has succeeded in two phase 3 trials in patients undergoing bunionectomy and hernia repair by meeting all their primary and key secondary points.
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Alexion’s rare blood disorder treatment ALXN121 succeeds in phase 3 study
By PBR Staff Writer
Alexion Pharmaceuticals' investigational long-acting C5 complement inhibitor, ALXN1210, has succeeded in the pivotal phase 3 study of patients with rare blood disorder, paroxysmal nocturnal hemoglobinuria (PNH).
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FDA puts clinical hold on Solid Biosciences' Duchenne gene therapy trial
By PBR Staff Writer
The US Food and Drug Administration (FDA) has placed a clinical hold on Solid Biosciences' IGNITE DMD phase Phase I/II trial for SGT-001 microdystrophin gene transfer in Duchenne muscular dystrophy (DMD).
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AbbVie’s Elagolix succeeds in second phase 3 uterine fibroid study
AbbVie, along with Neurocrine Biosciences, announced that the Phase 3 ELARIS UF-II study (M12-817) of elagolix met its primary endpoint.
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Janssen’s Invokana reduces cardiovascular risk in diabetes patients
The Janssen Pharmaceutical Companies of Johnson & Johnson has announced results of a new analysis showing that Invokana (canagliflozin) significantly reduced the risk of cardiovascular (CV) death or hospitalization for heart failure (HHF) in patients with type 2 diabetes (T2D) at high CV risk.
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Regeneron’s anti-cholesterol drug Praluent reduces death risk in trial
By PBR Staff Writer
Praluent (alirocumab), an anti-cholesterol drug being developed by Regeneron Pharmaceuticals and Sanofi, has succeeded in the Odyssey Outcomes trial by decreasing the risk of death and heart attack in high-risk patients.
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Summit Therapeutics extends enrolment in phase 2 PhaseOut DMD study
Summit Therapeutics has opened enrolment in a planned additional group in its phase 2 open label clinical trial dubbed PhaseOut DMD for its Duchenne muscular dystrophy (DMD) drug ezutromid.
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Novartis to use Science 37's technology in 10 clinical trials
By PBR Staff Writer
Novartis said that it will use Science 37's Network Oriented Research Assistant (NORA) technology in up to 10 clinical trials over the next three years.
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Boehringer Ingelheim, Lilly expand heart failure program for Jardiance with new clinical trials
Boehringer Ingelheim and Eli Lilly have unveiled plans to expand their clinical trial program for Jardiance in chronic heart failure with the EMPERIAL clinical trials.
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Dermira's acne drug fails in two phase 3 trials
By PBR Staff Writer
Dermira said that two phase 3 clinical trials testing its acne drug, olumacostat glasaretil, failed to meet their co-primary endpoints.
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Emergent, Valneva begin phase 1 trial of Zika vaccine candidate
Emergent BioSolutions and Valneva have commenced a phase 1 clinical trial in the US to evaluate the safety and immunogenicity of their vaccine candidate VLA1601, against Zika virus.
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Orano Med, RadioMedix recruit first patients in AlphaMedix phase 1 clinical trial
Orano Med and RadioMedix have recruited first three patients in the AlphaMedix phase 1 clinical trial.
Contract Research & Services > Clinical Trials > News
Sterna reports positive results in severe ulcerative colitis drug trial
By PBR Staff Writer
sterna biological has reported positive results from the SECURE study, a Phase 2a trial in patients with moderate to severe ulcerative colitis treated with its GATA-3 specific DNAzyme formulation SB012.
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