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Clinical Trials News

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46-60 of 4090 results
OncoMed’s small cell lung cancer drug tarextumab fails in phase 2 trial
By PBR Staff Writer
A phase 2 study of OncoMed Pharmaceuticals' tarextumab in small cell lung cancer has failed to meet its primary and secondary endpoints.
Contract Research & Services > Clinical Trials > News
Roche's emicizumab reduces bleeds in children with hemophilia A
By PBR Staff Writer
Interim data from the phase 3 HAVEN 2 study evaluating Roche's emicizumab for reducing bleeding episodes in children younger than 12 years of age with hemophilia A demonstrated a clinically meaningful treatment effect.
Contract Research & Services > Clinical Trials > News
Novan’s topical anti-fungal treatment SB208 succeeds in phase 2 trial
By PBR Staff Writer
A phase 2 trial has revealed that Novan’s topical and silicone based-gel, SB208, demonstrated a significant effect in the treatment of infections caused by dermatophytes such as Trichophyton rubrum (T. rubrum).
Contract Research & Services > Clinical Trials > News
OncoMed's demcizumab fails to meet primary endpoint in pancreatic cancer trial
OncoMed Pharmaceuticals’ demcizumab (anti-DLL4, OMP-21M18) has failed to meet its primary endpoint in the Phase 2 YOSEMITE clinical trial in combination with Abraxane (paclitaxel protein-bound particles for injectable suspension) (albumin bound) plus gemcitabine in previously untreated metastatic pancreatic cancer patients.
Contract Research & Services > Clinical Trials > News
Roche’s Alecensa shows significant effect over Pfizer’s Xalkori to treat ALK- positive NSCLC
By PBR Staff Writer
A phase III study has revealed that Roche’s Alecensa (alectinib) showed significant effect over Pfizer’s Xalkori (crizotinib) in the treatment of patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).
Contract Research & Services > Clinical Trials > News
Medivir’s CTCL drug remetinostat yields positive data in phase II study
Medivir has reported positive data from its phase II clinical trial of the topical, skin-directed histone deacetylase (HDAC) inhibitor, remetinostat, in early stage Cutaneous T-cell Lymphoma patients.
Contract Research & Services > Clinical Trials > News
Burosumab’s pediatric phase 2 studies in X-linked hypophosphatemia yield positive results
Ultragenyx Pharmaceutical and Kyowa Kirin International (KKI), a subsidiary of Kyowa Hakko Kirin (Kyowa Hakko Kirin), have reported positive 64-week data from a pediatric Phase 2 study of burosumab (KRN23) for X-linked hypophosphatemia (XLH) treatment in children aged between five and 12 years.
Contract Research & Services > Clinical Trials > News
Allergan to advance Botox trial to third phase for treatment of depression
By PBR Staff Writer
Allergan announced to advance its wrinkle treatment Botox to third phase after its phase II study showed a partial benefit in treating patients with major depressive disorder (MDD).
Contract Research & Services > Clinical Trials > News
Verona doses first patient in cystic fibrosis trial of RPL554
Verona Pharma has enrolled and dosed the first patient in a Phase 2a clinical study to evaluate RPL554, as a treatment option for cystic fibrosis (CF).
Contract Research & Services > Clinical Trials > News
Paratek’s pneumonia antibiotic succeeds in phase 3 trial
By PBR Staff Writer
A phase 3 study of Paratek Pharmaceuticals' omadacycline has met its primary and secondary endpoints in the treatment of patients with community-acquired bacterial pneumonia (CABP).
Contract Research & Services > Clinical Trials > News
GSK commences phase III study of mepolizumab in severe HES patients
By PBR Staff Writer
GlaxoSmithKline (GSK) has initiated a phase III study of its interleukin 5 (IL-5) antagonist, mepolizumab in hypereosinophilic syndrome (HES) patients.
Contract Research & Services > Clinical Trials > News
Amgen, UCB explore option of second course of treatment with evenity
Amgen and UCB have released results from the fourth year of a Phase 2 study demonstrating the safety and efficacy of a second course of treatment with evenity (romosozumab), an investigational candidate for postmenopausal women with osteoporosis.
Contract Research & Services > Clinical Trials > News
Corbus’ anabasum meets safety and tolerability goals in cystic fibrosis study
By PBR Staff Writer
A phase 2 trial evaluating Corbus Pharmaceuticals’ multiple doses of anabasum (Resunab) has met its primary objective in patients with cystic fibrosis, demonstrating an acceptable safety and tolerability profile with no severe adverse events.
Contract Research & Services > Clinical Trials > News
Ritter reports topline phase 2b/3 results for lactose intolerance treatment RP-G28
Ritter Pharmaceuticals' lactose intolerance treatment, RP-G28, demonstrated efficacy and clinically meaningful benefit in phase 2b/3 clinical trial.
Contract Research & Services > Clinical Trials > News
Summit to extend PhaseOut DMD trial for ezutromid
Summit Therapeutics has announced that, subject to regulatory approval, it will go ahead with the planned extension phase of PhaseOut DMD, a Phase 2 clinical trial studying the utrophin modulator ezutromid.
Contract Research & Services > Clinical Trials > News
46-60 of 4090 results