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Ultragenyx's hypophosphatemia drug succeeds in phase 3 study
Ultragenyx Pharmaceutical, Kyowa Hakko Kirin and Kyowa Kirin International have reported positive 24-week data from the randomized, double-blind, placebo-controlled Phase 3 trial of burosumab (KRN23) in X-linked hypophosphatemia (XLH) adult patients.
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Relypsa’s Veltassa shows consistent efficacy in phase 4 trial to treat hyperkalemia
By PKBR Staff Writer
Relypsa’s Veltassa (patiromer) has demonstrated consistent effficacy and safety in phase 4 Tourmaline study in patients with hyperkalemia.
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Mateon’s phase 2/3 trial in platinum-resistant ovarian cancer yields positive results
Mateon Therapeutics has revealed encouraging data from its first interim scheduled analysis of the ongoing phase 2/3 trial (FOCUS) in platinum resistant ovarian cancer (prOC) patients.
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OncoMed’s small cell lung cancer drug tarextumab fails in phase 2 trial
By PBR Staff Writer
A phase 2 study of OncoMed Pharmaceuticals' tarextumab in small cell lung cancer has failed to meet its primary and secondary endpoints.
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Roche's emicizumab reduces bleeds in children with hemophilia A
By PBR Staff Writer
Interim data from the phase 3 HAVEN 2 study evaluating Roche's emicizumab for reducing bleeding episodes in children younger than 12 years of age with hemophilia A demonstrated a clinically meaningful treatment effect.
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Novan’s topical anti-fungal treatment SB208 succeeds in phase 2 trial
By PBR Staff Writer
A phase 2 trial has revealed that Novan’s topical and silicone based-gel, SB208, demonstrated a significant effect in the treatment of infections caused by dermatophytes such as Trichophyton rubrum (T. rubrum).
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OncoMed's demcizumab fails to meet primary endpoint in pancreatic cancer trial
OncoMed Pharmaceuticals’ demcizumab (anti-DLL4, OMP-21M18) has failed to meet its primary endpoint in the Phase 2 YOSEMITE clinical trial in combination with Abraxane (paclitaxel protein-bound particles for injectable suspension) (albumin bound) plus gemcitabine in previously untreated metastatic pancreatic cancer patients.
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Roche’s Alecensa shows significant effect over Pfizer’s Xalkori to treat ALK- positive NSCLC
By PBR Staff Writer
A phase III study has revealed that Roche’s Alecensa (alectinib) showed significant effect over Pfizer’s Xalkori (crizotinib) in the treatment of patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).
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Medivir’s CTCL drug remetinostat yields positive data in phase II study
Medivir has reported positive data from its phase II clinical trial of the topical, skin-directed histone deacetylase (HDAC) inhibitor, remetinostat, in early stage Cutaneous T-cell Lymphoma patients.
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Burosumab’s pediatric phase 2 studies in X-linked hypophosphatemia yield positive results
Ultragenyx Pharmaceutical and Kyowa Kirin International (KKI), a subsidiary of Kyowa Hakko Kirin (Kyowa Hakko Kirin), have reported positive 64-week data from a pediatric Phase 2 study of burosumab (KRN23) for X-linked hypophosphatemia (XLH) treatment in children aged between five and 12 years.
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Allergan to advance Botox trial to third phase for treatment of depression
By PBR Staff Writer
Allergan announced to advance its wrinkle treatment Botox to third phase after its phase II study showed a partial benefit in treating patients with major depressive disorder (MDD).
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Verona doses first patient in cystic fibrosis trial of RPL554
Verona Pharma has enrolled and dosed the first patient in a Phase 2a clinical study to evaluate RPL554, as a treatment option for cystic fibrosis (CF).
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Paratek’s pneumonia antibiotic succeeds in phase 3 trial
By PBR Staff Writer
A phase 3 study of Paratek Pharmaceuticals' omadacycline has met its primary and secondary endpoints in the treatment of patients with community-acquired bacterial pneumonia (CABP).
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GSK commences phase III study of mepolizumab in severe HES patients
By PBR Staff Writer
GlaxoSmithKline (GSK) has initiated a phase III study of its interleukin 5 (IL-5) antagonist, mepolizumab in hypereosinophilic syndrome (HES) patients.
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Amgen, UCB explore option of second course of treatment with evenity
Amgen and UCB have released results from the fourth year of a Phase 2 study demonstrating the safety and efficacy of a second course of treatment with evenity (romosozumab), an investigational candidate for postmenopausal women with osteoporosis.
Contract Research & Services > Clinical Trials > News
166-180 of 4213 results