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Clinical Trials

Gilead’s Odefsey (Emtricitabine, Rilpivirine, Tenofovir Alafenamide) meets primary objective in two phase 3b studies Gilead Sciences announced that two Phase 3b switch studies evaluating Odefsey® (emtricitabine 200mg/rilpivirine 25mg/tenofovir alafenamide 25mg) for the treatment of HIV-1 infection met their primary objectives.
Contract Research & Services > Clinical Trials > News
Amgen and Allergan study finds biosimilar comparable to Roche’s Herceptin breast cancer drug By PBR Staff Writer
Amgen and Allergan have said that a late-stage trial of their treatment being developed as a biosimilar to Roche’s breast cancer drug trastuzumab (Herceptin) met its primary endpoint.
Contract Research & Services > Clinical Trials > News Transgene to continue phase 1/1b study with TG1050 in Chronic Hepatitis B patients The Safety Review Committee of the Phase 1/1b trial with TG1050, Transgene’s immunotherapy product candidate for the treatment of chronic hepatitis B virus (HBV) infection, has recommended that the study should continue.
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AstraZeneca’s Zavicefta meets main goals in phase III trial to treat hospital-acquired pneumonia
By PBR Staff Writer
AstraZeneca has unveiled positive results from a phase III trial of its Zavicefta antibiotic, a fixed dose combination of two active substances, ceftazidime and avibactam.
Contract Research & Services > Clinical Trials > News
Eiger doses first patient in phase 2 LIBERTY study of ubenimex in pulmonary arterial hypertension
Eiger BioPharmaceuticals has dosed the first patient in the Phase 2 LIBERTY study of Ubenimex in Pulmonary Arterial Hypertension.
Contract Research & Services > Clinical Trials > News
AstraZeneca’s Tagrisso meets primary endpoint in phase III 2nd-line lung cancer trial
By PBR Staff Writer
A Phase III trial evaluating AstraZeneca's Tagrisso lung cancer drug has met its primary endpoint in showing superior progression-free survival compared to standard chemotherapy.
Contract Research & Services > Clinical Trials > News
IntelGenx starts phase 1 clinical trial of montelukast
IntelGenx has started a phase 1 clinical trial of montelukast, a drug repurposing opportunity for the treatment of degenerative diseases of the brain, such as: mild cognitive impairment and Alzheimers disease, the most prominent form of dementia.
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Aptinyx starts dosing in phase 1 study of lead NMDA-receptor modulator, NYX-2925
Aptinyx has started dosing in a Phase 1, first-in-human study for its lead therapeutic candidate, NYX-2925.
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Sage Therapeutics’ postpartum depression drug demonstrates positive results in phase 2 trial
By PBR Staff Writer
Sage Therapeutics has unveiled positive top-line results including demonstration of 30-day durability from phase 2 clinical trial of SAGE-547 in severe postpartum depression (PPD).
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Celldex Therapeutics starts phase 1/2 trial of CDX-014 in advanced renal cell carcinoma
Celldex Therapeutics announced that enrollment has opened in its Phase 1/2 study of CDX-014 in advanced renal cell carcinoma (RCC). CDX-014 is a novel antibody-drug conjugate that targets the transmembrane protein T-cell immunoglobulin mucin-1 (TIM-1).
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CytRx unveils initial results of phase 3 trial of aldoxorubicin in patients with second-line STS
CytRx announced the results of an analysis of its global, randomized, Phase 3 clinical trial of aldoxorubicin compared to investigator's choice therapy in patients with relapsed or refractory soft tissue sarcomas (STS).
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Vernalis completes CCP-08 pivotal multiple-dose comparative bioavailability study
Vernalis has completed the CCP-08 pivotal multiple-dose comparative bioavailability study.
Contract Research & Services > Clinical Trials > News
Pfizer's Sutent meets primary endpoint in phase 3 kidney cancer trial
A phase 3 study of Pfizer’s Sutent has extended disease-free survival (DFS) versus placebo as an adjuvant therapy for patients with renal cell carcinoma (RCC) at high risk of recurrence after surgery.
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