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Clinical Trials

Arcus Biosciences secures funding to advance clinical programs for AB928 Clinical-stage biotechnology company Arcus Biosciences has completed a $107m series C financing, bringing the total equity capital to around $227m.
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Sage’s brexanolone meets primary endpoints in phase 3 postpartum depression trials Sage Therapeutics has reported positive top-line results from two phase 3 clinical trials with its i.v. formulation of brexanolone (USAN; formerly SAGE-547); Study 202B in severe postpartum depression (PPD) and Study 202C in moderate PPD.
Contract Research & Services > Clinical Trials > News Tricida announces closing of $57.5m series D financing Tricida has closed an oversubscribed $57.5m series D financing, bringing the company’s total capital raised to-date to $153.3m.
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Novartis’ breast cancer drug Kisqali succeeds in phase 3 study in premenopausal women
By PBR Staff Writer
Novartis’ Kisqali (ribociclib) combination therapy has succeeded in a phase 3 study in premenopausal women with hormone-receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer.
Contract Research & Services > Clinical Trials > News
Boehringer says Cyltezo and Humira have similar efficacy, safety in people with RA
Boehringer Ingelheim has revealed one-year data from VOLTAIRE-RA, a pivotal phase 3 clinical trial evaluating Cyltezo (adalimumab-adbm) with reference product Humira.
Contract Research & Services > Clinical Trials > News
Trial finds blood plasma infusions could help treat Alzheimer’s
By PBR Staff Writer
A team of researchers in the US have found that regular infusions of blood plasma from young donors could well be a new treatment option for Alzheimer’s disease.
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Sanofi, Alnylam present positive complete results of patisiran from phase 3 study in hATTR amyloidosis patients with polyneuropathy
Sanofi Genzyme, and Alnylam Pharmaceuticals have reported positive complete results from the Apollo Phase 3 study of patisiran, an investigational RNAi therapeutic being developed for patients with hereditary ATTR (hATTR) amyloidosis with polyneuropathy.
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GSK study shows COPD 'superiority' for Anoro Ellipta versus Stiolto Respimat
By PBR Staff Writer
GlaxoSmithKline’s (GSK) study showed that Anoro Ellipta is more effective than Stiolto Respimat in improving lung function in patients with chronic obstructive pulmonary disease (COPD).
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Novartis seeks FDA approval for second Kymriah indication
Novartis has submitted a supplemental Biologics License Application (sBLA) to the US Food and Drug Administration (FDA) for Kymriah (tisagenlecleucel) for the treatment of adult patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) who are ineligible for autologous stem cell transplant (ASCT).
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AbbVie says Elagolix reduces pelvic pain in two phase 3 extension studies
By PBR Staff Writer
AbbVie said that its gonadotropin-releasing hormone (GnRH) antagonist elagolix demonstrated sustained reduction in average monthly menstrual pelvic pain, non-menstrual pelvic pain and painful intercourse in two replicate Phase 3 extension studies.
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AbbVie’s psoriasis drug meets co-primary endpoints in three phase 3 trials
By PBR Staff Writer
AbbVie’s psoriasis drug risankizumab has met all co-primary and ranked secondary points in three pivotal phase 3 clinical trials.
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Novartis pediatric multiple sclerosis drug Gilenya shows significant effect in phase III trial
Novartis has announced full results from the phase III PARADIGMS study, investigating the safety and efficacy of Gilenya (fingolimod) versus interferon beta-1a, in children and adolescents (ages 10 to 17) with multiple sclerosis (MS).
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OncoQuest to collaborate with Tesaro in recurrent ovarian cancer setting
OncoQuest has entered into collaboration with Tesaro to conduct a proof-of-concept clinical trial evaluating the combination of oregovomab with ZEJULA (niraparib) in the recurrent ovarian cancer setting.
Contract Research & Services > Clinical Trials > News
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